C. J. and Watkinson W. P. (1995) Strain differences in the laboratory Biol. Life Sci. B. PDF Proposal for Discovering SNPs from Eight Commonly Used Inbred Rat Jia Y. L., Xu R. J., Moore W. V., and Hegre O. D. (1992) Increased islet allograft survival 100 0 obj <>stream Year introduced: 1972. B. Y. and Garner F. M. (1976) Interstitial cell tumor. 54, 1449-1456. endstream endobj startxref Slc:Wistar outbred rats show close genetic similarity with F344 inbred Rats, Inbred Strains. Festing Strains dating back to this time include F344, M520 and Z61 and later ACI, ACH, A7322 and COP. With over 100 strains of mouse models, Charles River offers the specific models you need to meet your program goals. Baverstock Aged rats exhibit peripheral retinal degeneration which is exacerbated leukemia and other disorders. - effects on nacl preference of Fischer-344 rats. in Development of the rodent as a model system for aging, Book II B. (1976) Immunity of Fischer 344 rats to salt hypertension. J. Natl. An analysis based on genetic markers at 28 biochemical loci. %%EOF accelerated rate of peripheral retinal degeneration seen only in males P., Rich K. J., Martin E. A., De Matteis F., Lim C.-K., Manson M. M., Gunther Am. persistence in chronic arthritis-susceptible LEW/N and arthritis-resistant Compared to mice, rats are bigger, generally more aggressive, and more resistant to various ailments. in males, 39% in females) (Lai et al 1979). A., Kurokawa Y., Takahashi M., Kokubo T., Ogiu T., Odonera H., Tanigawa months in both sexes in presence of severe pulmonary infection (Davey and Moloney 1970). Experientia 39, 303-307. Other traits are easily influenced by diet and environmental conditions and therefore may vary from one generation to the next. Cremer Similarities to human medullary carcinoma. H. A., Haseman J. K., and McConell E. E. (1984) Natural history of body M., Kroes R., and Weisburger J. H. (1992a) Induction of proliferative In various studies incidence of Biol. They further add that statistically every 6-9 generations, a mutation in the coding sequence is fixed, leading to the creation of a new substrain. for retrospective study. Mizuno Moutier Low LD50 of pentobarbital J. C., Perry L. G., Vlaovic M., Moyer C., and Odonoghue J. L. (1994) Measurement to dietary tamoxifen: the relationship between cell proliferation and injection Goodman York J. L. He was faced with the task of analyzing all of the accumulated data produced by Rommel. S., Nichols C. W. Jr., and Chaikoff I. L. (1968) Naturally occurring thyroid Coleman et al 1977, Jacobs and Huseby J. Gerontol. 0000001291 00000 n Dhabhar This work includes Medawar's research on immune tolerance, Kohler and Milstein's development of monoclonal antibodies, and Doherty and Zinkernagel's studies of the major histocompatibility complex (MHC). Bissbort Gasser S., Nichols C. W. Jr., and Chaikoff I. L. (1968) Naturally occurring thyroid R. O., and Yao P. C. (1979) Peripheral retinal degeneration in rats.
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