All rights reserved. Portions of this document last updated: April 01, 2023. Post-finasteride syndrome (PFS) describes persistent sexual, neurological, physical, and mental adverse reactions in patients who have taken finasteride, a 5-alpha reductase type II enzyme inhibitor used to treat hair loss (under the brand name Propecia or generics) and/or enlarged prostate (Proscar or generics). Unauthorized use of these marks is strictly prohibited. 2004;6(Suppl. Studies examining the six-month prostate size after water vapor thermal therapy demonstrated a 29% reduction in prostate size by MRI. National Library of Medicine Some alpha-l-adrenergic drugs for example, doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin) and tamsulosin (selective alpha 1-A receptor blocker Flomax) have been used for this purpose. I Didn't take any other medicine while using Finasteride but I am having beer or two in the evenings. Post-Finasteride Syndrome. Literature Review - PubMed The researchers reported that 11.8% of those reports involved persistent sexual dysfunction and 7.9% depression. The Post-Finasteride Syndrome Foundation 2023, Support Program Connects PFS Patients Worldwide, First-Ever PFS Diagnostic Criteria Published in Medical Literature, Loss of morning and spontaneous erections, Sexual anhedonia, loss of pleasurable orgasm, Female-like breast development and enlargement, Myopathy, including muscle weakness, cramps, stiffness and tetany (twitching), Melasma (brownish macules and patches that typically affect sun-exposed areas on the face), Lipoatrophy (localized loss of fat tissue), Optic neuropathy (damage inflicted on the optic nerve), Ocular toxicity (includes inflammation and atrophy of the optic nerve and inner retina, loss of white matter, and gliosis of the occipital and parietal lobes causing various degrees of blindness), Increased fat deposition, obesity and elevated body mass index, Reduced HDL cholesterol, raised fasting glucose and triglycerides, Impaired problem solving, decreased comprehension. Five articles on the syndrome have been published in Spain, although no review has been published.The objectives of this article are to review the world literature, including the Spanish . The reports authors recommended that physicians gradually increase the dose to 10 mg unless troublesome side effects occur. An analysis of six studies found that finasteride only improved BPH symptoms in men with an initial prostate volume of over 40 cubic centimeters finasteride did not reduce symptoms in men with smaller glands. Details on the five muscle disorders, according the Mayo Clinic, are as follows: Rhabdomyolysis Myopathy Myalgia Myasthenia Creatine kinase elevation 3 5 The incidence of post-finasteride syndrome is unknown, as are the biological mechanisms, but we know Finasteride (Oral Route) Proper Use - Mayo Clinic
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