Supplied: 50 mg, 100 mg, 150 mg tablet. May be administered once a day; twice a day dosing is recommended for total daily doses of 1000 mg or more or in patients who experience gastrointestinal tolerance. The dosage of amiodarone should be kept at the lowest effective level. Questions. Amiodarone Hydrochloride Injection, 50 mg/mL is supplied in: Bookshelf Assuming that the plan was not to load the patient, you could simply convert to an equivalent IV dose. Oral: 250-500 mg/dose every 3-6 hours or 500 mg to 1 g every 6 hours extended release; usual dose: 50 mg/kg/24 hours; maximum: 4 g/24 hours. PULMONARY TOXICITY: This drug has several potentially fatal toxicities, the most important of which is pulmonary toxicity (hypersensitivity pneumonitis or interstitial/alveolar pneumonitis) that has resulted in clinically manifest disease at rates as high as 10% to 17% in some series of patients with ventricular arrhythmias given doses around 400 mg/day, and as abnormal diffusion capacity without symptoms in a much higher percentage of patients. Infusion: 1 to 3 weeks Initial Daily Dose of Oral Cordarone : 600-800 mg. Alqahtani A. Atrial fibrillation post cardiac surgery trends toward management. Half-life: 38-48 hrs. If the QTc >15% of baseline, or if the QTc is >500 msec (550 msec in patients with ventricular conduction abnormalities), dofetilide should be adjusted. Hypotension should be treated initially by slowing the infusion; additional standard therapy may be needed, including the following: vasopressor drugs, positive inotropic agents, and volume expansion. Injection: 80 mg/ml (10 ml) (gluconate). Postoperative atrial fibrillation following cardiac surgery: a persistent complication. Peak serum concentrations after single 5 mg/kg 15-minute intravenous infusions in healthy subjects range between 5 and 41 mg/L. A patient started on oral (PO) amiodarone approximately 1 week ago (400 mg/day). The initial rate of infusion should be monitored closely and should not exceed that prescribed in DOSAGE AND ADMINISTRATION. INFUSION Duration of Cordarone I.V. Druga PO to IV Considerations Comments Amiodarone (Cordarone) Use an IV dose thats 50% of the PO maintenance A naive look at this scenario gives the impression that the patient has not been started on an oral loading dose of amiodarone. Many factors (ie, age, weight, sex, other comorbid conditions, indication for amiodarone use [atrial vs ventricular arrhythmias as well as treatment vs prophylaxis for an arrhythmia], and history of prior antiarrhythmic use) need to be considered to weigh risk vs benefit of amiodarone use as well as a decision to load or not to load. by 25% full replacement dose qwk if hyperactivity risk; give PO form on empty stomach, 30-60min before morning meal; IM/IV dose is 50-75% of PO dose [>12 yo, growth/puberty complete] The initial infusion rate should not exceed 30 mg/min. Intravenous amiodarone is a class III antiarrhythmic agent which has been reported to be safe and most effective in various clinical settings, without an associated increase in mortality rate. The patient is now taking nothing by mouth (NPO), and the physician would like to The patient is now taking nothing by mouth (NPO), and the physician would like to switch to intravenous (IV) amiodarone. It is used in patients who have already been treated with other medicines that did not work well. Onset of action: 2-10 minutes. Intravenous to Oral Transition of Amiodarone (IOTA): Effect After the first 24 hours, the maintenance infusion rate of 0.5 mg/min (720 mg/24 hours) should be continued utilizing a concentration of 1 to 6 mg/ml (Cordarone I.V. Anti-Arrhythmics - GlobalRPH Ocular: Ophthalmic examination, including fundoscopy and slit-lamp examination, Respiratory: History, physical exam, chest X-ray, and pulmonary function tests, including diffusion capacity.