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To prevent osteoporotic fractures, combined calcium and vitamin D supplementation is recommended at the correct dosage (1,0001,200 mg calcium and 800 IU of vitamin D per day). Supplementation should be targeted on vulnerable groups such as elderly and institutionalised people, patients with osteoporosis and individuals on glucocorticoids. Numerous trials have shown that calcium and vitamin D supplementation is effective and safe. In particular, no increased cardiovascular risk was observed. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. Here are a few questions to consider asking your doctor: You can also learn more about osteoporosis treatment options here. No, Prolia isnt a bisphosphonate. But if youre planning to have surgery, you may need to take a break It strengthens your bones by stopping certain bone cells called osteoclasts from breaking down your bones. This drug may not be the right treatment for your condition if you have certain medical conditions or other factors that affect your health. They may be able to help you identify the cause. In certain cases, Prolia may have contraindications (not be recommended) for you due to a higher risk for side effects. But weight gain may occur with other medications you take or other health conditions you have. You may wonder how Prolia compares with the alternative drug Reclast. Serious side effects from Prolia can occur, but they arent common. Learn more about your health after menopause. Prolia Prolia solution is available in one strength: 60 milligrams per milliliter (mg/mL). Call your doctor for medical advice about side effects. Is the ketogenic diet right for autoimmune conditions? It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Both medications are approved to treat certain people with osteoporosis, as well as people with other conditions. Although very rare, Prolia can cause serious dental problems and jaw-related side effects. Do not share this medicine with another person, even if they have the same symptoms you have. And some of these side effects are more common with certain uses of Prolia. This medicine is only given in a clinic, doctor's office, or other health care setting and will not be stored at home. Prolia may cause serious side effects. If youve noticed hair loss since starting Prolia treatment, talk with your doctor. Your doctor or pharmacist can tell you more about the potential side effects of Prolia and ways to reduce them. Theyre commonly used to treat osteoporosis. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. If youd like to learn more about Prolia, talk with your doctor or pharmacist. But theyre each effective in treating osteoporosis and preventing bone loss. Having dental procedures, including tooth extractions, during Prolia treatment may increase your risk of dental side effects. If you want to stop taking Prolia, tell your doctor. Other drugs may interact with denosumab, including prescription and over-the-counter medicines, vitamins, and herbal products. If you miss a dose of Prolia, you should receive your injection as soon as you can.